Saget was pronounced dead Sunday after first responders were called by officials from The Ritz-Carlton in Orlando, WFTV reported.
The sheriff’s department said Saget unlocked the hotel room door at 2:17 a.m. Sunday and was supposed to check out later that day.
His family had tried to reach him, but when they were unable to do so, they called the hotel to ask the security staff to check on the “Full House” star.
Security officers knocked on his door but didn’t get a response, so they entered and found him unresponsive in bed.
Security said they checked for breathing and a pulse and found neither. He also was, according to the incident report, “cold to the touch, yellow and clammy.”
He was face up, with his left arm across his chest and his right arm on the bed, WFTV reported. There were no signs of trauma or foul play found.
The hotel security staff called 911.
Orange County Fire and Rescue was first on the scene and pronounced Saget dead at 4:18 p.m., WFTV reported.
Hotel management called Saget’s wife, Kelly Rizzo, after consulting the hotel’s legal team, to tell her of his death.
The scene was turned over to homicide investigators as a matter of procedure.
The Orange County medical examiner’s office said they found no evidence of drug use or foul play in Saget’s death, WFTV reported.
Saget’s cause and manner of death “are pending further studies and investigation which may take up to 10-12 weeks,” Chief Medical Examiner Joshua Stephany said in a statement to CNN.
Saget starred as patriarch Danny Tanner on ABC’s “Full House,” which ran from 1987 to 1995, and then again on its spinoff, “Fuller House,” which aired for five seasons on Netflix, CNN reported. He also was the host of “America’s Funniest Home Videos,” also on ABC, from 1990 to 1997.
He was the narrator on CBS’s “How I Met Your Mother.” He also was frequently on tour as a standup comedian. His last show was on Saturday outside of Jacksonville, Florida, hours before his death. He was scheduled to appear in West Palm Beach, Florida, later this month.
Bob Saget Bob Saget arrives at the Film Independent Spirit Awards on Saturday, Feb. 25, 2017, in Santa Monica, Calif. (Photo by Jordan Strauss/Invision/AP) (Jordan Strauss/Jordan Strauss/Invision/AP)
Bob Saget Host Bob Saget, left, and honoree Jason Alexander share a laugh at the 13th Annual Lupus LA Orange Ball at the Beverly Wilshire Hotel on Thursday, May 9, 2013 in Beverly Hills, Calif. (Photo by Chris Pizzello/Invision/AP) (Chris Pizzello/Chris Pizzello/Invision/AP)
Bob Saget Host Bob Saget poses alongside an Oscar statue before the Academy of Motion Picture Arts and Sciences 40th Student Academy Awards at the Samuel Goldwyn Theater on Saturday, June 8, 2013 in Beverly Hills, Calif. (Photo by Chris Pizzello/Invision/AP) (Chris Pizzello/Chris Pizzello/Invision/AP)
Bob Saget Bob Saget arrives at the premiere of "Jackass Presents Bad Grandpa" at the TCL Chinese Theatre on Wednesday, Oct. 23, 2013 in Los Angeles. (Photo by Richard Shotwell/Invision/AP) (Richard Shotwell/Richard Shotwell/Invision/AP)
Bob Saget Bob Saget, left, and Dave Coulier attend the 30th annual Scleroderma Foundation Benefit at the Beverly Wilshire hotel on Friday, June 16, 2017, in Beverly Hills, Calif. (Photo by Chris Pizzello/Invision/AP) (Chris Pizzello/Chris Pizzello/Invision/AP)
Bob Saget Bob Saget attends the 2nd Annual Rebels with a Cause at Paramount Pictures Studios on Thursday, March 20, 2014 in Los Angeles. (Photo by Annie I. Bang /Invision/AP) (Annie I. Bang/Annie I. Bang/Invision/AP)
Bob Saget Bob Saget, left, and Jimmy Kimmel attend the 30th annual Scleroderma Foundation Benefit at the Beverly Wilshire hotel Friday, June 16, 2017, in Beverly Hills, Calif. (Photo by Chris Pizzello/Invision/AP) (Chris Pizzello/Chris Pizzello/Invision/AP)
Bob Saget Host Bob Saget, center, joins together with guests Jack Black, left, and Kevin Nealon before the Cool Comedy's Hot Cuisine Benefit for the Scleroderma Research Foundation at the Four Seasons Hotel on Tuesday, April 30, 2013 in Beverly Hills, Calif. (Photo by Chris Pizzello/Invision/AP) (Chris Pizzello/Chris Pizzello/Invision/AP)
Bob Saget Comedian Bob Saget performs on stage at KAABOO Texas at AT&T Stadium on Sunday, May 12, 2019, in Arlington, Texas. (Photo by Amy Harris/Invision/AP) (Amy Harris/Amy Harris/Invision/AP)
Bob Saget Bob Saget arrives at the People's Choice Awards at the Microsoft Theater on Wednesday, Jan. 18, 2017, in Los Angeles. (Photo by Jordan Strauss/Invision/AP) (Jordan Strauss/Jordan Strauss/Invision/AP)
Bob Saget Bob Saget, left, and John Mayer attend the Opening Night of the 2018 Beverly Hills Film Festival at the TCL Chinese 6 Theatres on Wednesday, April 4, 2018, in Los Angeles. (Photo by Richard Shotwell/Invision/AP) (Richard Shotwell/Richard Shotwell/Invision/AP)
Bob Saget Bob Saget, left, and Kelly Rizzo arrive at the Los Angeles premiere of "Robin Williams: Come Inside My Mind" at the TCL Chinese Theatre on Wednesday, June 27, 2018. (Photo by Chris Pizzello/Invision/AP) (Chris Pizzello/Chris Pizzello/Invision/AP)
Bob Saget John Stamos and Bob Saget seen at Open Road Presents the World Premiere of "Mother's Day" at TCL Chinese Theatre on Wednesday, April 13, 2016, in Hollywood. (Photo by Steve Cohn/Invision for Open Road Films/AP Images) (Steve Cohn/Steve Cohn/Invision/AP)
Bob Saget Lara Saget, left, and Bob Saget arrive at the 56th annual GRAMMY Awards at Staples Center on Sunday, Jan. 26, 2014, in Los Angeles. (Photo by Jordan Strauss/Invision/AP) (Jordan Strauss/Jordan Strauss/Invision/AP)
Bob Saget Aubrey Saget, from left, Bob Saget and Lara Saget attend the 30th annual Scleroderma Foundation Benefit at the Beverly Wilshire hotel on Friday, June 16, 2017, in Beverly Hills, Calif. (Photo by Chris Pizzello/Invision/AP) (Chris Pizzello/Chris Pizzello/Invision/AP)
Bob Saget Bob Saget, left, and Kelly Rizzo attend the Opening Night of the 2018 Beverly Hills Film Festival at the TCL Chinese 6 Theatres on Wednesday, April 4, 2018, in Los Angeles. (Photo by Richard Shotwell/Invision/AP) (Richard Shotwell/Richard Shotwell/Invision/AP)
Bob Saget Bob Saget, left, and John Stamos arrive at the Los Angeles premiere of "Mother's Day" at the TCL Chinese Theatre on Wednesday, April 13, 2016. (Photo by Richard Shotwell/Invision/AP) (Richard Shotwell/Richard Shotwell/Invision/AP)
Bob Saget EXCLUSIVE - John Stamos and, from left, Andrea Barber, Candace Cameron Brue, Lori Loughlin, Bob Saget during night one of the Television Academy's 2018 Creative Arts Emmy Awards at the Microsoft Theater on Saturday, Sept. 8, 2018, in Los Angeles. (Photo by Phil McCarten/Invision/AP) (Phil McCarten/Phil McCarten/Invision/AP)
Bob Saget Jodie Sweetin, front row from left, Jeff Franklin, Candace Cameron-Bure, John Brotherton, Dave Coulier, Scott Weinger, Lori Laughlin, Andrea Barber, and bottom row from left, Juan Pablo di Pace, Bob Saget, and John Stamos pose in the press room with the award for favorite premium comedy series for "Fuller House" at the People's Choice Awards at the Microsoft Theater on Wednesday, Jan. 18, 2017, in Los Angeles. (Photo by Jordan Strauss/Invision/AP) (Jordan Strauss/Jordan Strauss/Invision/AP)
Bob Saget From left, Jeff Franklin, John Stamos, Lori Loughlin, Jodie Sweetin, Andrea Barber, Chief Content Officer of Netflix -Ted Sarandos, Michael Campion, Candace Cameron Bure, Elias Harger, Soni Bringas, Bob Saget, Dave Coulier and Juan Pablo Di Pace attend the premiere of "Fuller House" on February 16, 2016 in Los Angeles. (Jordan Strauss/Invision/AP) (Jordan Strauss/Jordan Strauss/Invision/AP)
Bob Saget Bob Saget, left, and Christin Kalaskie arrives at the Cool Comedy: Hot Cuisine Gala Benefit at the Beverly Wilshire Hotel on Friday, June 5, 2015, in Beverly Hills, Calif. (Photo by Rich Fury/Invision/AP) (Rich Fury/Rich Fury/Invision/AP)
Bob Saget EXCLUSIVE - John Stamos, from left, Andrea Barber, Bob Saget, Candace Cameron Bure and Lori Loughlin attend night one of the Television Academy's 2018 Creative Arts Emmy Awards at the Microsoft Theater on Saturday, Sept. 8, 2018, in Los Angeles. (Photo by John Salangsang/Invision/AP) (John Salangsang/John Salangsang/Invision/AP)
Bob Saget IMAGE DISTRIBUTED FOR STARLIGHT CHILDREN'S FOUNDATION - Bob Saget, left and Mr. T attend the Starlight Awards at the Skirball Cultural Center on Wednesday, Sept. 25, 2013, in Los Angeles. (Photo by Jordan Strauss/Invision for Starlight Children's Foundation/AP Images) (Jordan Strauss/Invision for Starlight Children's Foundation)
Bob Saget Jack Black, left, and Bob Saget arrive at the Cool Comedy: Hot Cuisine Gala Benefit at the Beverly Wilshire Hotel on Friday, June 5, 2015, in Beverly Hills, Calif. (Photo by Rich Fury/Invision/AP) (Rich Fury/Rich Fury/Invision/AP)
Bob Saget Actor/comedian Bob Saget performs with David Shaw of The Revivalists during KAABOO 2019 at the Del Mar Racetrack and Fairgrounds on Sunday, Sept. 15, 2019, in Del Mar, Calif. (Photo by Amy Harris/Invision/AP) (Amy Harris/Amy Harris/Invision/AP)